This effect may last for a few days after you stop using this medicine. Check with your doctor before taking any of these medicines while you are using this medicine. Oxycodone extended-release capsules or tablets should only be used by patients who have already been taking opioid pain medicines. If you are uncertain whether or not you are opioid-tolerant, check with your doctor before using this medicine.
Patient Counseling Information
Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed OXYCONTIN. Addiction can occur at recommended doses and if the drug is misused or abused. Patients who experience breakthrough pain may require a dosage adjustment of OXYCONTIN or may need rescue medication with an appropriate dose of an immediate-release analgesic. If the level of pain increases after dose stabilization, attempt to identify the source of increased pain before increasing the OXYCONTIN dosage. Because steady-state plasma concentrations are approximated in 1 day, OXYCONTIN dosage may be adjusted every 1 to 2 days. While useful tables of opioid equivalents are readily available, there is substantial inter-patient variability in the relative potency of different opioids.
The plan may also include non-medicine treatments such as relaxation techniques, massage therapy, or transcutaneous electrical stimulation (TENS). Discuss with the patient and caregiver the availability of naloxone for the emergency treatment of opioid overdose, both when initiating and renewing treatment with OXYCONTIN. Consider prescribing naloxone, based on the patient’s risk factors for overdose, such as concomitant use of CNS depressants, a history of opioid use disorder, or prior opioid overdose. The presence of risk factors for overdose should not prevent the proper management of pain in any given patient.
- Its potency and efficacy make it a valuable medication for pain relief when used correctly under medical supervision.
- Compared to young adults, the plasma concentrations of oxycodone were increased approximately 15% see CLINICAL PHARMACOLOGY.
- Educate patients and caregivers on how to recognize respiratory depression and emphasize the importance of calling 911 or getting emergency medical help right away in the event of a known or suspected overdose.
- Your doctor may decrease your dose if you have sleep apnea (stop breathing for short periods during sleep) while using this medicine.
- Call emergency services if you have problems breathing or staying awake.
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You can find out more on how to properly throw away your medicines at /drugdisposal. Oxycodone/acetaminophen should not be used if you have trouble breathing, severe asthma, or other lung problems. Medical supervision and support are critical for safe detoxification, especially for patients with high doses or prolonged use. While oxycodone is beneficial, it carries risks and side effects that must be carefully monitored.
Throw away any unused or expired oxycodone by taking the medicine to a U.S. You can find out more on how to properly throw away your medicines at /drugdisposal. Oxycodone should not be used if you have trouble breathing, severe asthma, or other lung problems. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Forms and Dosage
Initiate dosing using OXYCONTIN 10 mg orally every 12 hours. This opioid is often the drug of choice for addictive use and can easily lead to dependency. Some patients may develop tolerance for Oxycontin and need to be slowly weaned off the drug.
What other information should I know?
Physical dependence may lead to withdrawal symptoms if treatment is stopped suddenly. However, severe withdrawal symptoms can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. In an individual physically dependent on opioids, administration of the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity of the withdrawal symptoms experienced will depend on the degree of physical dependence and the dose of the antagonist administered. If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be initiated with care and by titration with smaller than usual doses of the antagonist. Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in OXYCONTIN-treated patients may increase oxycodone plasma concentrations and prolong opioid adverse reactions.
Symptoms of overdose may include the following:
This may not be a complete list of medicines that can interact oxycodone uses side effects precautions with oxycodone/acetaminophen. Many other medicines may alter the blood levels of oxycodone/acetaminophen. Tell your healthcare provider about all medicines that you take or have recently taken.
Addiction, Abuse, And Misuse
- As a guideline for adults, the total daily oxycodone dosage usually can be increased by 25% to 50% of the current total daily dosage, each time an increase is clinically indicated.
- Be sure to follow the prescription and your healthcare provider’s directions closely when it comes to taking any medications and never modify dosages on your own.
- If you breastfeed while taking this medication, seek medical care right away if you notice the child has slow or noisy breathing, is unusually sleepy or not able to wake up, or is limp.
- If you feel that the medicine is not working as well, do not use more than your prescribed dose.
Oxycontin (oxycodone hydrochloride) is available as controlled-release tablets in strengths of 10, 15, 20, 30, 40, 60, 80, and 160 mg tablets (60 mg and above used only for opioid tolerant patients). OxyContin (oxycodone hydrochloride) is an opioid drug used for the management of moderate to severe pain, usually for an extended time period. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use.
Difficulty In Swallowing And Risk For Obstruction In Patients At Risk For A Small Gastrointestinal Lumen
Don’t take this drug again if you’ve ever had an allergic reaction to it. If you develop these symptoms, call 911 or go to the nearest emergency room. This means you may need to take it with other medications.
Also consider prescribing naloxone if the patient has household members (including children) or other close contacts at risk for accidental ingestion or overdose. If naloxone is prescribed, educate patients and caregivers on how to treat with naloxone. see DOSAGE AND ADMINISTRATION, Addiction, Abuse, And Misuse, Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants and OVERDOSE. There is substantial inter-patient variability in the relative potency of different opioid drugs and formulations. Therefore, a conservative approach is advised when determining the total daily dosage of OXYCONTIN.
Oxycodone should not be used if you have a blockage in your gut (bowel obstruction) or have narrowing in your stomach or your intestines. Oxycodone should not be used if you have a condition called paralytic ileus, where your intestines are unable to move food through them. Your pharmacist can tell you all of the ingredients in the specific oxycodone products they stock. While less common, the most serious side effects of oxycodone are described below, along with what to do if they happen.
Before taking oxycodone/acetaminophen, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. People who are 65 and older can be at greater risk for some side effects from oxycodone/acetaminophen. Talk to your healthcare provider about your risks if you are in this age group. The kidneys of older adults may not work as well as they used to.
